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Table 1 Summary of antibody titres and subclasses, electrophysiological and morphological data of rats injected with IgG of different patients. Significant differences (between patients and controls) are marked with*

From: Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model

Rats injected with IgG of

Acute patient (n = 12)

Low titre patient (n = 15)

Chronic patient (n = 20)

Control animals (n = 36)

Titre of IgG subclasses (predominant subclass in bold type)

IgG1

1:1000

1:100

1:500

Negative

IgG2

negative

1:100

1:1000

IgG3

1:7500

1:1000

1:5000

IgG4

1:500

1:1000

1:15,000

Binding subclass

In vitro

IgG3, (IgG4)

IgG4

IgG4

None

In vivo

IgG3

No binding detectable

IgG4

Conduction block

83.3%*

0%

35%

13.2%

Loss of F waves

66.7%*

0%

40%*

0%

Median CMAP ratio (distal/proximal) pre-/post-injection (mV)

1.14 (1.03–1.34)

1.18 (1.04–1.24)

1.11 (0.89–1.38)

1.12 (0.88–2.49)

3.32 (1.04–20.25)*

1.18 (0.92–1.71)

1.35 (1.07–13.35)

1.23 (1.08–5.12)

Median SNAP pre-/post-injection (μV)

20.0 (6.9–29.9)

17.4 (10.0–59.9)

18.0 (0–26.1)

17.8 (2.9–106)

8.8 (0–18.7)*

13.2 (0.3–63.0)

13.7 (1.3–30.9)

15.7 (3.6–39.2)

Median fall latency (s)

205 (111–336)

230 (64–396)

231 (100–500)

223 (71–401)

155 (54–222)*

186 (76–297)

185 (84–389)

180 (67–343)

Median standing time right hind paw (s)

0.23 (0.17–0.28)

0.24 (0.19–0.37)

0.22 (0.17–0.52)

0.24 (0.15–0.46)

0.18 (0.08–0.25)*

0.24 (0.18–0.45)

0.22 (0.11–0.44)

0.24 (0.15–0.43)

Median print area right hind paw (cm2)

1.39 (0.54–2.18)

1.89 (1.04–2.74)

1.18 (0.45–1.73)

1.30 (0.64–2.35)

0.88 (0.09–2.21)*

2.07 (1.30–2.98)

1.04 (0.32–1.51)

1.61 (0.74–2.91)

Median maximum intensity right hind paw (AU)

217 (182–229)

222 (207–232)

212 (180–219)

210 (173–232)

177 (83–234)*

220 (206–234)

202 (94–221)

215 (165–235)

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Journal of Neuroinflammation

ISSN: 1742-2094