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Table 1 Summary of antibody titres and subclasses, electrophysiological and morphological data of rats injected with IgG of different patients. Significant differences (between patients and controls) are marked with*

From: Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model

Rats injected with IgG of Acute patient (n = 12) Low titre patient (n = 15) Chronic patient (n = 20) Control animals (n = 36)
Titre of IgG subclasses (predominant subclass in bold type) IgG1 1:1000 1:100 1:500 Negative
IgG2 negative 1:100 1:1000
IgG3 1:7500 1:1000 1:5000
IgG4 1:500 1:1000 1:15,000
Binding subclass In vitro IgG3, (IgG4) IgG4 IgG4 None
In vivo IgG3 No binding detectable IgG4
Conduction block 83.3%* 0% 35% 13.2%
Loss of F waves 66.7%* 0% 40%* 0%
Median CMAP ratio (distal/proximal) pre-/post-injection (mV) 1.14 (1.03–1.34) 1.18 (1.04–1.24) 1.11 (0.89–1.38) 1.12 (0.88–2.49)
3.32 (1.04–20.25)* 1.18 (0.92–1.71) 1.35 (1.07–13.35) 1.23 (1.08–5.12)
Median SNAP pre-/post-injection (μV) 20.0 (6.9–29.9) 17.4 (10.0–59.9) 18.0 (0–26.1) 17.8 (2.9–106)
8.8 (0–18.7)* 13.2 (0.3–63.0) 13.7 (1.3–30.9) 15.7 (3.6–39.2)
Median fall latency (s) 205 (111–336) 230 (64–396) 231 (100–500) 223 (71–401)
155 (54–222)* 186 (76–297) 185 (84–389) 180 (67–343)
Median standing time right hind paw (s) 0.23 (0.17–0.28) 0.24 (0.19–0.37) 0.22 (0.17–0.52) 0.24 (0.15–0.46)
0.18 (0.08–0.25)* 0.24 (0.18–0.45) 0.22 (0.11–0.44) 0.24 (0.15–0.43)
Median print area right hind paw (cm2) 1.39 (0.54–2.18) 1.89 (1.04–2.74) 1.18 (0.45–1.73) 1.30 (0.64–2.35)
0.88 (0.09–2.21)* 2.07 (1.30–2.98) 1.04 (0.32–1.51) 1.61 (0.74–2.91)
Median maximum intensity right hind paw (AU) 217 (182–229) 222 (207–232) 212 (180–219) 210 (173–232)
177 (83–234)* 220 (206–234) 202 (94–221) 215 (165–235)