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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke

Fig. 5

1810034E14Rik improved brain damage after 1 h MCAO/24 h reperfusion. a The expression of lncRNA-1810034E14Rik in the infarcted cortex at day 1, day 2, day 3, and day 7 was tested by RT-qPCR. b A 1810034E14Rik lentiviral vector expressing GFP was infected in the mice cortex by a stereotactic instrument. c The expression of 1810034E14Rik was examined by RT-qPCR in the cortex after injection. The neurological severity scores (d), rota-rod test (e), and grip strength (f) were performed to evaluate functional outcome after MCAO. g Brain water content was examined to measure brain edema severity. h, i Infarct volume after MCAO was confirmed by TTC staining. The data represents mean ± SEM. n = 15, *P < 0.05, **P < 0.01, and ***P < 0.001 versus the sham group; #P < 0.05 and ##P < 0.01 versus the MCAO group

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