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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways

Fig. 7

Schematic diagram of P2Y4R signal activated by Tat via PI3K/Akt and ERK pathways in astrocyte-mediated neuron death. Under soluble Tat stimulation, P2Y4R are upregulated in astrocytes via PI3K/Akt and ERK pathways, which increases inflammatory process and ATP release to damage neuron, thus exacerbating the HAND process

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Journal of Neuroinflammation

ISSN: 1742-2094