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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model

Fig. 1

Progression of hypertension and histological damage in deoxycorticosterone acetate (DOCA)-salt rats. a Experimental grouping for histological analysis of the model animals. b Systolic blood pressure in DOCA2W, DOCA3W, and DOCA4W was compared with that in the control. Values are expressed as the means ± SEM (n = 3 in each group, *p < 0.05). c Hematoxylin and eosin or Klüver-Barrera staining of brain tissues. In DOCA3W, focal vascular remodeling including the perivascular space enlargements (open arrowheads) and the formation of vacuoles in the white matter (closed arrowheads) appeared. In DOCA4W, cerebral hemorrhage (dotted area) and myelinoclasis lesions were found. Scale bars 500 μm (1–4), 20 μm (5–12), and 40 μm (13–16)

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