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Table 5 General, demographic, and clinical findings of KIR haplotype, HLA allele, and their combination frequencies in subjects with acute ischemic stroke in relation to TOAST subtype

From: HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke

Variables LAAS (n 45) Lacunar (27) Cardioembolic (40) p
Male (n/%) 29 (64.4) 12 (44.4) 15 (37.5) 0.057
Hypertension (n/%) 39 (86.6) 24 (88.8) 36 (90) 0.85
Diabetes (n/%) 20 (44.4) 13 (48.14) 15 (37.5) 0.40
Hypercholesterolaemia (n/%) 24 (53.3) 6 (22.22) 10 (25) 0.011
Hypertriglyceridaemia (n/%) 12 (26.66) 5 (18.51) 9 (22.5) 0.84
Atrial fibrillation (n/%) 8 (17.77) 8 (29.62) 35 (87.5) 0.0001
Previous stroke (n/%) 21 (46.66) 13 (48.14) 21 (52.5) 0.90
2DL1 (n/%) 27 (60) 13 (48.14) 22 (55) 0.75
2DL2 (n/%) 20 (44.4) 7 (25.92) 12 (30) 0.20
2DL3 (n/%) 39 (86.6) 17 (62.96) 29 (72.5) 0.033
2DL4 (n/%) 40 (88.8) 16 (59.25) 26 (65) 0.010
2DL5A (n/%) 6 (13.33) 1 (3.73) 7 (17.5) 0.37
2DL5B (n/%) 13 (28.8) 11 (40.7) 14 (35) 0.76
2DS1 (n/%) 7 (15.5) 7 (25.9) 9 (22.5) 0.52
2DS2 (n/%) 14 (31.1) 12 (44.4) 17 (42.5) 0.61
2DS3 (n/%) 13 (28.8) 6 (22.2) 10 (25) 0.92
2DS4 (n/%) 20 (44.4) 10 (37.03) 16 (40) 0.90
2DS5 (n/%) 5 (11.11) 4 (14.81) 8 (20) 0.73
3DL1 (n/%) 34 (75.55) 13 (48.14) 28 (70) 0.073
3DL2 (n/%) 37 (82.22) 14 (51.85) 25 (62.5) 0.016
3DL3 (n/%) 36 (80) 13 (48.14) 22 (55) 0.015
3DS1 (n/%) 23 (51.1) 14 (51.85) 23 (57.5) 0.35
2DP1 (n/%) 39 (86.6) 19 (70.37) 30 (75) 0.26
3DP1 (n/%) 3 (6.66) 4 (14.81) 10 (25) 0.11
HLA-A-Bw4 (n/%) 8 (17.77) 9 (33.3) 12 (30) 0.33
HLA-A haplotype (n/%) 18 (40) 12 (44.4) 20 (50) 0.68
HLA-C1 haplotype (n/%) 13 (28.88) 5 (18.51) 19 (47.5) 0.069
HLA-C2 haplotype (n/%) 12 (26.66) 9 (33.3) 14 (35) 0.83
HLA-B-Bw4-T (n/%) 14 (31.11) 4 (14.81) 12 (30) 0.37
HLA-B-Bw4 I (n/%) 3 (6.66) 1 (3.7) 6 (15) 0.42
2DL2-HLA-C1 (n/%) 7 (15.5) 4 (14.81) 12 (30) 0.24
2DL3-HLA-C1 (n/%) 15 (33.3) 8 (29.62) 13 (32.5) 0.67
2DS2-HLA-C1 (n/%) 13 (28.87) 11 (40.74) 14 (35) 0.54
2DS2-HLA-C2 (n/%) 8 (17.77) 9 (33.3) 11 (27.5) 0.40
2DL2-HLA-C2 (n/%) 8 (17.77) 7 (25.92) 9 (22.5) 0.24
2DS1-HLA-C2 (n/%) 5 (11.11) 2 (7.40) 7 (17.5) 0.67
2DL1-HLA-C1 (n/%) 2 (4.4) 4 (14.81) 9 (22.5) 0.047
2DL2-HLA-C1 (n/%) 7 (15.5) 4 (14.81) 12 (30) 0.24
2DL1-HLA-C2 (n/%) 7 (15.5) 3 (11.11) 7 (17.5) 0.88
  1. KIR killer cell immunoglobulin-like receptor, HLA human leukocyte antigen