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Table 7 Logistic regression model to predict TOAST subtype of acute ischemic stroke in relation of prevalence of HLA allele and of HLA-KIR interactions

From: HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke

Variable Beta Exp(B) 95% confidence interval for Exp(B) p value
Lacunar subtype
 HLA-A-Bw4 1.04 2.853 0.86–9.39 0.08
 HLA-C1 − 1.24 0.28 0.07–1.15 0.07
 HLA-C2 − 0.29 0.74 0.21–2.61 0.65
 HLA-B-Bw4T − 0.82 0.43 0.11–1.73 0.23
 HLA-B-Bw4I − 1.132 0.32 0.03–3.15 0.33
 2DL2-HLA-C1 − 0.50 0.60 0.16–2.19 0.44
 2DL3-HLA-C1 − 0.64 0.52 0.17–1.57 0.25
 2DS2-HLA-C1 0.49 1.647 0.59–4.57 0.33
 2DS-2HLA-C2 0.76 2.156 0.67–6.85 0.19
 2DL2-HLA-C2 0.06 1.063 0.31–3.56 0.92
 2DS1-HLA-C2 − 0.73 0.48 0.08–2.86 0.42
 2DL1-HLA-C1 0.18 1.197 0.28–4.96 0.80
 2DL1-HLA-C2 − 0.24 0.78 0.17–3.49 0.75
 aplotipoHLA-A − 0.38 0.68 0.25–1.79 0.44
LAAS subtype
 HLA-A-Bw4 − 1.322 0.26 0.07–1.01 0.05
 AB haplotype − 0.13 0.87 0.27–2.8 0.82
 HLA-C1 0.31 1.37 0.29–6.36 0.68
 HLA-C2 − 0.46 0.62 0.14–2.66 0.52
 HLA-B-Bw4T 1.006 2.73 0.59–12.53 0.19
 HLA-B-Bw4I 0.87 2.4 0.19–30.19 0.49
 2DL2-HLA-C1 0.10 1.1 0.26–4.66 0.89
 2DL3-HLA-C1 0.48 1.63 0.47–5.60 0.43
 2DS-2HLA-C1 − 0.89 0.4 0.12–1.33 0.13
 2DS2-HLA-C2 − 1.35 2.58 0.06–1.03 0.05
 2DL2-HLA-C2 − 0.12 0.88 0.22–3.41 0.85
 2DS1-HLA-C2 0.79 2.2 0.31–15.67 0.43
 2DL1-HLA-C1 − 1.46 0.23 0.03–1.64 0.14
 2DL1-HLA-C2 − 0.01 0.98 0.19–5.03 0.98
Cardioembolic subtype
 HLA-A-Bw4 − 0.48 0.61 0.15–2.40 0.48
 AB-haplotype − 1.18 0.3 0.08–1.15 0.08
 HLA-C1 2.36 10.63 2.10–53.78 0.004
 HLA-C2 1.24 3.48 0.71–17.07 0.12
 HLA-B-Bw4T 0.96 2.63 0.51–13.38 0.24
 HLAB-B-w4I 2.135 8.45 0.71–100.69 0.09
 2DL2-HLA-C1 0.64 1.91 0.43–8.33 0.38
 2DL3-HLA-C1 0.67 1.96 0.52–7.29 0.31
 2DS2-HLA-C1 0.26 1.3 0.37–4.56 0.67
 2DS2-HLA-C2 − 0.05 0.95 0.21–4.14 0.94
 2DL2-HLA-C2 − 0.29 0.74 0.18–3.05 0.68
 2DS1-HLA-C2 0.68 1.97 0.27–14.06 0.49
 2DL1-HLA-C1 0.60 1.82 0.40–8.31 0.43
 2DL1-HLA-C2 0.78 2.19 0.39–12.19 0.36
  1. LAAS large artery atherosclerotic stroke, KIR killer cell immunoglobulin-like receptor, HLA human leukocyte antigen