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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

Fig. 1

JC124 treatment blocks TBI-induced activation of NLRP3 inflammasome in the injured brain. Representative western blotting images showing the 120 kDa band of NLRP3 (a) and 24 kDa band of ASC (c) detected in the ipsilateral hippocampal lysate from sham, TBI-vehicle, and TBI-JC124 animals. Quantification analysis showed significantly higher level of NLRP3 (b) and ASC (d) in the injured vehicle group compared to sham (p < 0.05, p < 0.01, respectively). In injured JC124-treated group, the injury-induced upregulation of both NLRP3 (b) and ASC (d) was significantly reduced compared to vehicle group (p < 0.01), and the expression level for both proteins was similar to sham

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Journal of Neuroinflammation

ISSN: 1742-2094