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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

Fig. 4

JC124 treatment reduced the post-injury Caspase 1 expression level. a) Representative Western blotting image showing the 50kD band of pro-caspase 1 and 10kD band of caspase P10 fragment detected in the ipsilateral hippocampal lysate from sham, TBI-vehicle and TBI-JC124 animals. b) Quantification analysis showed significantly higher level of pro-caspase 1 in both injury groups compared to sham and a reduction in JC124 treated group compared to vehicle group (p < 0.001 and p < 0.05, respectively). c) The expression level of caspase 1P10 fragment was significantly higher in the TBI-vehicle group compared to sham and TBI-JC124 group (p < 0.01 and p < 0.0001, respectively)

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