Fig. 5

The role of Nrf2 signaling on ICA-affected functions of glial cells. After ICA treatment for 10 days, the protein levels of pro-inflammatory mediators, such as TNF-α and iNOS (a), and the production of neurotrophic factors, such as GDNF and BDNF (b), in the midbrain of WT and Nrf2 KO mice were measured by western blotting. Results were mean ± SEM from 5 to 6 mice. *p < 0.05 compared with the control group, ^#p < 0.05 compared with 6-OHDA-treated group