Fig. 1
From: Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
Defining dystrophic and plaque-associated neuropil areas. a An example EM image displaying a microglial cell body in plaque- and dystrophic-associated region of the ventral hippocampus CA1 in APPSwe-PS1Δe9 model mice. b Two microglial cell bodies and a microglial process showing IBA1 immunoreactivity surround a fAβ plaque and associated dystrophy. c A microglial cell body contacts both a dystrophic neurite and a fAβ plaque while a second microglial cell contacts a blood vessel. d A microglial cell body and its proximal process displaying IBA1 immunoreactivity encircle a fAβ plaque. Other microglial processes, discontinuous to the cell body in ultrathin section, can also be seen. bv blood vessel, m microglia. Dystrophy and fAβ plaques are labeled throughout the figure