Fig. 6
From: Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
Microglial ultrastructure in post-mortem hippocampal samples from two human AD patients. a, b Examples of IBA1-immunopositive microglial cell bodies and processes surrounding fAβ plaques in the post-mortem hippocampus from an individual diagnosed with AD (Braak stage 5). c–e Insets from A and B, showing: c a microglial cell body contacting a dystrophic neurite, d a microglial process encircling two dystrophic neurites, and e another microglial process wrapping around other neuropil elements. f–j IBA1-immunopositive microglial cell body and processes from post-mortem hippocampal tissue from a second individual diagnosed with AD (also Braak stage 5). g–j Microglial processes seen making contacts with dystrophic neurites and dendritic spines, some of them receiving synapses from axon terminals, as well as containing phagocytic inclusions and lysosomes. dn dystrophic neurite, Ly lysosome, m microglia, mt mitochondrion, s dendritic spine, t axon terminal. Non-empty phagocytic inclusions are pseudocolored in green