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Table 1 Ultrastructural analysis of microglial cell bodies in wild-type (WT) littermate controls versus APPSwe-PS1Δe9 mice

From: Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology

  WT APP
Mean ± SEM Mean ± SEM
Area (μm2) 17.53 ± 1.06 22.64 ± 1.13*
Perimeter (μm) 21.98 ± 1.01 25.71 ± 1.41
Circularity (a.u.) 0.482 ± 0.02 0.487 ± 0.018
Roundness (a.u.) 0.594 ± 0.027 0.606 ± 0.187
Solidity (a.u.) 0.838 ± 0.0139 0.838 ± 0.01
Lipid body (n) 0.667 ± 0.159 0.488 ± 0.10
Fibrillar materials inclusion (n) 0 0.390 ± 0.096**
Phagocytic (%) 78.6 ± 6.40 79.3 ± 4.50
Total inclusion (n) 1.810 ± 0.187 1.707 ± 0.123
Non-empty inclusion (n) 0.833 ± 0.148 1.024 ± 0.119
Empty inclusion (n) 1.50 ± 0.194 0.976 ± 0.111
ER dilation (n) 0.50 ± 0.11 0.80 ± 0.11
Extracellular debris (n) 1.667 ± 0.212 0.854 ± 0.131**
Primary lysosome (n) 0.1667 ± 0.108 0.171 ± 0.064
Secondary lysosome (n) 0.762 ± 0.186 0.548 ± 0.109
Tertiary lysosome (n) 0.643 ± 0.17 0.402 ± 0.096
Total lysosome (n) 1.00 ± 0.21 0.89 ± 0.138
  1. a.u. arbitrary unit, n number per microglial cell body