Table 1 Ultrastructural analysis of microglial cell bodies in wild-type (WT) littermate controls versus APP^Swe-PS1Δe9 mice

Area (μm²)

17.53 ± 1.06

22.64 ± 1.13*

Perimeter (μm)

21.98 ± 1.01

25.71 ± 1.41

Circularity (a.u.)

0.482 ± 0.02

0.487 ± 0.018

Roundness (a.u.)

0.594 ± 0.027

0.606 ± 0.187

Solidity (a.u.)

0.838 ± 0.0139

0.838 ± 0.01

Lipid body (n)

0.667 ± 0.159

0.488 ± 0.10

Fibrillar materials inclusion (n)

0

0.390 ± 0.096**

Phagocytic (%)

78.6 ± 6.40

79.3 ± 4.50

Total inclusion (n)

1.810 ± 0.187

1.707 ± 0.123

Non-empty inclusion (n)

0.833 ± 0.148

1.024 ± 0.119

Empty inclusion (n)

1.50 ± 0.194

0.976 ± 0.111

ER dilation (n)

0.50 ± 0.11

0.80 ± 0.11

Extracellular debris (n)

1.667 ± 0.212

0.854 ± 0.131**

Primary lysosome (n)

0.1667 ± 0.108

0.171 ± 0.064

Secondary lysosome (n)

0.762 ± 0.186

0.548 ± 0.109

Tertiary lysosome (n)

0.643 ± 0.17

0.402 ± 0.096

Total lysosome (n)

1.00 ± 0.21

0.89 ± 0.138