Table 3 Ultrastructural analysis of microglial processes in wild-type (WT) littermate controls versus APP^Swe-PS1Δe9 mice

Area (μm²)

0.4111 ± 0.021

0.3957 ± 0.020

Perimeter (μm)

3.476 ± 0.13

3.409 ± 0.13

Circularity (a.u.)

0.465 ± 0.1

0.499 ± 0.01*

Roundness (a.u.)

0.483 ± 0.009

0.508 ± 0.009

Solidity (a.u.)

0.761 ± 0.008

0.780 ± 0.007*

Lipidic inclusion (n)

0.139 ± 0.025

Fibrillar materials inclusion (n)

0

0.0133 ± 0.007

Phagocytic process (%)

0.3179 ± 0.024

0.2289 ± 0.02

Total inclusion (n)

0.4923 ± 0.043

0.3578 ± 0.037

Non-empty inclusion (n)

0.210 ± 0.026

0.189 ± 0.027

Empty inclusion (n)

0.292 ± 0.032

0.182 ± 0.024

ER dilation (n)

0.021 ± 0.008

0.04 ± 0.009

Extracellular debris (n)

0.380 ± 0.038

0.249 ± 0.027*

Total lysosome (n)

0.0153 ± 0.0062

0.0422 ± 0.015

Primary lysosome (n)

0.005 ± 0.003

0.009 ± 0.007

Secondary lysosome (n)

0.01 ± 0.005

0.03 ± 0.009

Tertiary lysosome (n)

0

0.016 ± 0.008

Encircled Aβ (n)

0

0.016 ± 0.009

Encircled synaptic element (n)

0.085 ± 0.02

0.20 ± 0.03**

Encircled dendritic spine (n)

0.06 ± 0.016

0.10 ± 0.018*

Encircled axonal terminal (n)

0.02 ± 0.008

0.08 ± 0.01***

Encircled degraded structure (n)

0.015 ± 0.007

0.029 ± 0.009