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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Fig. 2

Baicalin reversed CUMS-induced depressive behavior by alleviating neuroinflammation. a The effects of baicalin treatment on the behavioral evaluation in CUMS-induced mice (n = 12). The sucrose preference test (a, first), the crossing number in OPT (a, second), the immobility time in TST (a, third), and the immobility time in FST (a, fourth). b The pathological section results of baicalin’s effects on CUMS mice (n = 3). Nissl staining in the hippocampal CA1 region and its statistical analysis (b, first), and immunohistochemistry staining of TLR4 in area CA1 of the hippocampus and its statistical analysis (b, second) (scale bar 20 μm, n = 3 in each test). c The successive effects of baicalin on IL-1β, IL-6, and TNF-α in the hippocampus of CUMS mice (n = 8). All of the data are presented as means ± SEM. #p < 0.05, ##p < 0.01 vs. control; *p < 0.05, **p < 0.01 vs. CUMS

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