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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Fig. 6

Baicalin inhibited FoxO1 transactivation and TLR4 expression in the hippocampus of CUMS mice in a manner dependent on PI3K/AKT. a Western blot was performed to determine the levels of p-PI3K, p-AKT, p-FoxO1, and TLR4 in the hippocampus of CUMS mice after treatment with baicalin and LY294002 (n = 4). b Representative protein bands of p-FoxO1 in the cytoplasmic fractions and FoxO1 in the nuclear extractions. Data were normalized to the control group and presented as means ± SEM. #p < 0.05, ##p < 0.01, ###p < 0.005 vs. control; *p < 0.05, **p < 0.01 vs. CUMS; &p < 0.05, &&p < 0.01 vs. CUMS+BA60

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