Study | Characteristics of MDD samples | Number of participants per group | Brain regions | Method | |
---|---|---|---|---|---|
MDD | HC | Â | |||
Serra-Blasco et al. (2013) [76] | 22 with first-episode, 22 with remitted–recurrent, and 22 with treatment-resistant/chronic MDD | 66 | 32 | dmPFC, left insula | Voxel-based morphometry |
Treadway et al. (2015) [77] | Medication-free MDD | 52 | 51 | Dentate, dmPFC | Volumetric analyses |
Stratmann et al. (2014) [78] | 35 with first-episode and 97 with rMDD | 132 | 132 | Right hippocampus, right amygdala | Voxel-based morphometry |
Meng et al. (2014) [79] | 25 with rMDD | 25 | 25 | Right putamen | Graph-based methods |
Greicius et al. (2007) [80] | MDD | 28 | 20 | sgACC | Independent component analysis |
Jacobs et al. (2016) [81] | 17 with active MDD and 34 with remitted MDD | 51 | 26 | Left PCC and left inferior frontal gyrus, right middle frontal gyrus, left amygdala with the right anterior insula, caudate and claustrum | Functional connectivity |
Lythe et al. (2015) [84] | 31 MDD without relapse and 25 MDD with relapse | 56 | 39 | Right superior anterior temporal lobe and the sgACC | Functional connectivity |
Workman et al. (2016) [85] | 30 MDD without relapse and 17 MDD with relapse | 47 | 35 | Left sgACC, right sgACC | Functional connectivity |
Zaremba et al. (2018) [86] | 23 MDD without relapse and 37 MDD with relapse | 60 | 54 | Insular and dlPFC | Voxel-based morphometry |