Skip to main content

Table 3 Representative MRI studies investigating a putative association between inflammation and structural/functional changes in the brain in MDD

From: Role of inflammation in depression relapse

Study

Characteristics of MDD samples

Number of participants per group

Brain regions

Method

MDD

HC

 

Felger et al. (2016) [98]

Medically stable MDD

48

0

Ventral striatum and vmPFC

Functional connectivity

Meier et al. (2016) [99]

 

73

91

mPFC

Cortical volume, thickness, and surface area

Frodl et al. (2012) [100]

MDD

40

43

Hippocampus

Manual tracing of the bilateral hippocampal and amygdala structure

  1. Abbreviations: HC healthy controls, MDD major depressive disorder, mPFC medial prefrontal gyrus, vmPFC ventromedial prefrontal gyrus