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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain

Fig. 5

Paeoniflorin inhibited the response of astrocyte and microglia and reduced inflammation. a, b Paeoniflorin (40 mg/kg, i.p.) significantly decreased the expression of GFAP and IBA-1 induced by CCI in the spinal cords (n = 4). c Paeoniflorin (40 and 60 mg/kg, i.p.) significantly reduced the expression of IL-1β and TNF-α in the spinal cord induced by CCI in the spinal cords (n = 4). d Paeoniflorin administration for 5 days distinctly suppressed the upregulation of CGRP in the spinal cord (n = 4). The lumbar spines (L1–L6) were collected and analyzed 2 h after the last drug administration (day 18 after CCI surgery). Quantification of immunofluorescence was represented as mean fluorescence intensity in the superficial dorsal horns (n = 6 images per animal). PF, paeoniflorin. Significant differences were revealed following one-way ANOVA (*P < 0.05, **P < 0.01, ***P < 0.001 vs. control; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. CCI group; Bonferroni post hoc tests)

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