Fig. 11

NOX activity in wild-type mice treated with IL-10 after glutamate administration. NOX activity was evaluated in wild-type mice (WT) treated with NaCl 0.9%(S.S.), only glutamate 1 M (− IL-10) or glutamate + 0.4 ng/mL of IL-10 (+ IL-10) as detailed in the “Methods” section. The determination of NOX activity was measured as the change in fluorescence intensity resulting from the dihydroethidium (DHE) oxidation to ethidium (Et) in striatal homogenates after 0.5, 1, 3, 6, 12, and 24 h after glutamate administration. Data are expressed as fold change of Et fluorescence relative to saline without IL-4. Values are means ± SEM of three independent experiments. *p < 0.05 vs the corresponding saline control; ^ϕp < 0.05 vs the corresponding time of mice treated with glutamate alone