Fig. 3

NOX-2 activity during excitotoxic damage in wild-type and NOX-2 KO mice. NOX activity was evaluated as the change of fluorescence intensity resulting from dihydroethidium (DHE) oxidation to ethidium (Et) in striatum homogenates of WT and NOX-2 KO mice treated with glutamate (1 M) 0.5, 1, 3, 6, 12, and 24 h after glutamate administration. Data are expressed as fold change of Et fluorescence relative to WT saline. Values are means ± SEM of four independent experiments. *p < 0.05 vs the corresponding saline control; ^ϕp < 0.05 vs the corresponding wild-type mouse (WT) treated with glutamate