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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization

Fig. 3

Drug then CFA. Drug dosing is indicated with green boxes (5 days of drug, 2 days wash out) and CFA injection is indicated by red line. “Days” indicate days after CFA. a Mechanical allodynia and b thermal hyperalgesia were prolonged by prior exposure to morphine but not ZH853, despite the fact that ZH853 produced greater antinociception in the paw pressure test 24 h after implantation of the minipumps (d). In the CatWalk test (c), morphine-treated animals showed exaggerated functional impairment (guarding the left paw) within the first few days after CFA injection versus vehicle- and ZH853-treated animals. n = 7 for all groups. Error bars indicate SEM. + = veh vs morphine, # = veh vs ZH853, * = morphine vs 853.*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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