Fig. 5

Drug then paw incision (PI). “Days” indicate days after paw incision. Drug was given for 5 days and stopped for 2 days prior to incision. a Mechanical allodynia developed in all groups following paw incision, but ZH853-treated animals recovered faster than vehicle- or morphine-treated animals. b Thermal hyperalgesia was severe and long-lasting in all drug treatment groups, but ZH853 prevented LS as indicated by lack of unmasking by naltrexone. c CatWalk variables changed in response to paw incision but not by drug group. n indicated in bar graphs. Dashed lines indicate difference versus morphine. Error bars indicate SEM. + = veh vs morphine, # = veh vs ZH853, * = morphine vs 853. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001