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Table 3 Time to recovery analysis: drug then CFA

From: Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization

  1. Comparison of each time point to the group baseline to determine when that group recovered. Total time of significant hypersensitivity (days in pain) is noted in the right column. Morphine prolonged recovery (von Frey) or had no impact on time to recovery (Hargreaves) compared to vehicle treatment. However, ZH853 expedited recovery versus vehicle and morphine treatment. “Day” indicates the number of days since CFA injection. Drug was given for 5 days and stopped for 2 days prior to CFA. Two-way ANOVAs for von Frey and Hargreaves separately. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001