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Table 4 Time to recovery analysis: paw incision (PI) then drug

From: Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization

  1. Comparison to baseline. Total time of significant hypersensitivity (days in pain) is noted in the right column. ZH853 reduced the time to recovery for allodynia and thermal hyperalgesia versus vehicle and morphine treatment. Morphine prolonged thermal hyperalgesia. “Day” indicates the number of days since paw incision. Two-way ANOVAs for von Frey and Hargreaves were conducted separately. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001