Fig. 1
From: Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain
Experimental NEC induces macroscopic changes in the brain. a Representative photos of harvested brains of NEC and breastfed control pups at 9 days of life. b Compared to breastfed control, NEC pups had significantly lower brain weights. The brain of both NEC and control pups were weighed immediately after harvest. c Compared to breastfed control, NEC pups had higher brain-to-body weight ratios. Body weights were measured prior to brain harvest. d Hematoxylin and eosin-stained coronal sections of NEC and breastfed control brains were used for the cerebral cortex thickness measurements. Blue arrows indicate the anatomical boundary between the cerebral cortex and the hippocampus where the cortex thickness measurements were initiated. e Compared to breastfed control, the cerebral cortex of NEC pups was thinner. Scale bar = 500 μm