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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

Fig. 2

Wild-type (WT) mice displayed a significant reduction in home-cage activity by the fifth paraquat injection (10 mg/kg; ip), and this effect was reversed by LRRK2 knockout (KO) (a) but unaffected by G2019S (GS-Tg) transgenic overexpression (c). As a measure of nesting behavior, which requires fine motor skills and is influenced by stress, nestlet building was assessed in the 24 h following the fifth paraquat injection. Paraquat treatment markedly reduced nest building in WT mice, whereas LRRK2 KO prevented this deficit (b) but was unaffected by G2019S mutation (d). *p < 0.05, relative to respective controls

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