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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

Fig. 3

The paraquat treatment regimen (black bars) induced an elevation of plasma corticosterone levels, relative to saline treatment (white bars), and this elevation was significantly blunted in LRRK2 knockout (KO) mice (a). The G2019S (GS-Tg) transgenic mutation alone induced a significant corticosterone elevation that was similar to that induced by paraquat in non-transgenic mice (b). In both the LRRK2 KO and G2019S studies, paraquat significantly reduced striatal levels of BDNF in the absence of any effect of genotype (c, d). While hippocampal 5-HT1A levels were not affected by paraquat or LRRK2 KO (e), the G2019S mutation did elevate 5-HTIA, relative to saline treatment (f). *p < 0.05, relative to respective saline-treated controls, +p < 0.05, difference between genotypes

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