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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice

Fig. 7

Deletion of TREK-1 increases the necrosis and apoptotic of neurons accompanied by retarded functional recovery after ICH. a A representative Nissl staining picture shows that TREK-1 deficiency exacerbated the necrosis of neurons. Scale bar = 50 μm. b Counting of Nissl-stained neurons in the perihematoma region on days 1 and 3 after ICH. c Apoptotic neurons in the perihematoma region on days 1 and 3 were detected by double staining of TUNEL (green), NeuN (red), and DAPI (blue). Scale bar = 50 μm. d Statistical analysis of percentage of apoptotic neurons on days 1 and 3 post-ICH in WT ICH and TREK-1 KO ICH groups. e–g Statistical analysis of Longa scores (e), corner turn scores (f), and forelimb placing scores (g) in WT and TREK-1 KO groups. Values are expressed as mean ± SEM (n = 10), and data were evaluated by Student’s independent sample t test. *p < 0.05, WT ICH group versus KO ICH group

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