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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

Fig. 3

IL1β production is induced by LPS and addition of IL1β results in synaptophysin loss. LPS-treated OHSCs show increased IL1β protein levels in the culture medium after 24 h (***p = 0.0008) (n = 7) (a). IL1β mRNA is also elevated in 3 weeks in vitro wild-type cultures treated with LPS for the last week in vitro (**p = 0.0069) (n = 4) (b). Treatment with 20 ng/ml IL1β (c) results in reduced synaptophysin protein (**p = 0.0081) (d) with no significant change in PSD95 (p = 0.86) (e) (n = 4). All statistics were conducted using a paired t test to account for matched control and treated OHSCs from the same animal. Error bars = mean ± SEM

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