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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

Fig. 4

HDAC3 inhibition prevents hyperglycemia-IL1β (HG-IL1β) insult-induced tight junction loss in cultured HBMEC monolayer. a Representative Western blot gel images of ZO-1, VE-cadherin, Occludin, and Claudin-5 in cultured HBMEC after HG-IL1β insult with/without RGFP966 treatment. b–e. Quantifications of junction protein ZO-1, VE-cadherin, Occludin, and Claudin-5 protein expression in cultured HBMEC. Data are expressed as mean ± SEM. *P < 0.05 vs. norm, #P < 0.05 vs. HG-IL1β, n = 6 cultures per groups. f Immunocytochemistry of ZO-1, VE-cadherin, and Claudin-5 in cultured HBMEC after HG-IL1β with/without RGFP966 treatment. White arrows indicate disrupted alignment of tight junction proteins

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Journal of Neuroinflammation

ISSN: 1742-2094