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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Meningitic Escherichia coli-induced upregulation of PDGF-B and ICAM-1 aggravates blood-brain barrier disruption and neuroinflammatory response

Fig. 1

Meningitic E. coli infection increases production as well as secretion of PDGF-BB in hBMECs. a Meningitic E. coli PCN033 induced a time-dependent increase of PDGF-B transcription in hBMECs. GAPDH was used as the reference control. b Western blot analysis revealed a significant decrease of PDGF-B protein in the lysates of hBMECs in response to infection. β-actin was used as a loading control, and densitometry was performed to analyze differences among the samples. c, d Western blot analysis of the PDGF-BB dimer in either lysates or the concentrated culture supernatant of hBMECs after infection. β-actin was used as the loading control, and densitometry was performed to analyze differences

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Journal of Neuroinflammation

ISSN: 1742-2094