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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Meningitic Escherichia coli-induced upregulation of PDGF-B and ICAM-1 aggravates blood-brain barrier disruption and neuroinflammatory response

Fig. 2

PDGF-BB was upregulated in meningitic E. coli-challenged mice. a, b ELISA analysis of PDGF-BB in serum and brain lysates from challenged mice exhibiting different symptoms (n = 3). Data are presented as mean ± SD from three individual mice in each group. c The brains of moribund and control mice were taken and analyzed for the expression of PDGF-BB via IF. PCN033-induced perivascular PDGF-BB was labeled in green. CD34 was specifically applied for labeling the blood vessels in red. The cell nucleus was stained in blue with DAPI. Scale bar indicates 50 μM. d The brains of moribund and control mice were subjected to PDGF-BB expression by IHC. PDGF-BB around the vessels was indicated by red arrows (infection group) or black arrows (mock group). Scale bar indicates 50 μM

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