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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis

Fig. 5

Chemokine levels (pg/mL) in CSF and serum of TMEV-IDD mice, R-EAE mice, and sham controls. The levels of CXCL13, CXCL12, and CCL19 were measured in individual CSF (a, c, e) and serum (b, d, f) specimens by Luminex bead immunoassays. CSF chemokine levels were higher in TMEV-IDD mice as compared to both R-EAE mice and sham controls. Conversely, serum chemokine levels were higher in R-EAE as compared to both TMEV-IDD mice and sham controls. Data are representative of 3 independent experiments (n = 11) for TMEV-IDD and 1 experiment (n = 6) for R-EAE. Since the effect for age was not significant, sham mice were analyzed as all from one population (n = 5). Data are shown as mean ± SEM. ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05

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