Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome

Table 2 Associations (simple regression analysis) between fatigue (fVAS scores) and selected variables

Independent variables	Estimate	Std. error	R ²	P
Depression (BDI) scores	1.42	0.42	0.20	0.001
Pain (SF-36) scores*	0.48	0.13	0.23	< 0.001
IL-1Ra	0.52	0.24	0.09	0.04
IL-1RII	0.13	0.16	0.01	0.41
IL-6	− 3.47	2.43	0.04	0.16
S100B	0.05	0.04	0.03	0.22
Hcrt1	− 0.04	0.14	0.002	0.76

Abbreviations: BDI Beck Depression Inventory, SF-36 36-item short form survey instrument, IL-1Ra interleukin 1 receptor antagonist, IL-1RII interleukin 1 receptor type 2, IL-6 interleukin 6, S100B S100 calcium binding-protein B, Hcrt1 hypocretin 1
*SF-36 pain scores are reported according to the transformed scale with high scores indicating high bodily pain and low scores indicating low bodily pain

ISSN: 1742-2094