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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Augmented β2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size

Fig. 1

Clenbuterol administration after stroke reduces macrophage density and increases macrophage size. a Experimental design. Three hours after photothrombotic cortical stroke, C57BL/6J mice received clenbuterol or saline vehicle control, 1 mg/kg i.p. bolus injection, and 1 mg/kg/day via subcutaneous pump. Mice were sacrificed 3 days post-stroke. b, c Representative images of CD68-immunopositive cells in the stroke border (b) and peri-infarct cortex (c) of clenbuterol- or saline-treated mice. Quantification of the percent image area covered by CD68 immunostaining is shown to the right of the photomicrographs, Student’s t test. d Qualitative scoring of size and density of CD68+ cells in the stroke border, Mann-Whitney test. n = 8–10 mice per group. Bars, mean ± SEM; *p < 0.05, ***p < 0.001; scale bar, 50 μm

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