Fig. 6

Selective knockout of the β2-adrenergic receptor in microglia/MDMs does not alter cellular morphology after stroke. a Experimental design. Cx3cr1^CreER x Adrb2^flox/flox mice were treated with tamoxifen for 3 days to selectively knock down Adrb2 expression in microglia and MDMs. Five days later, we induced photothrombotic stroke, and mice were sacrificed 3 days after stroke. b Representative images of CD68-immunopositive cells in the stroke border of Adrb2^cKO or littermate Adrb2^WT controls. c Quantification of the percent image area covered by CD68 immunostaining showed no difference between Adrb2^cKO and Adrb2^WT mice, Student’s t test. n = 9–12 mice per group. Bars, mean ± SEM; scale bar, 50 μm