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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury

Fig. 3

JQ1 treatment reduces macrophage and microglia reactivity after SCI. a Iba1 and b GFAP immunoreactivity quantification at 800 μm rostrally and caudally from the injury epicenter. Histograms represent the mean integrated density ± SEM quantified in gray (left) and white (right) matter in the ventral zone of the spinal cord sections. Representative images of Iba1 (a) and GFAP (b) at 200 and 400 μm, respectively, rostral to the epicenter are shown. Scale bar = 100 μm. N = 4–5 mice per group. *p < 0.05 compared to vehicle-treated animals and #p < 0.05 compared to short-term-treated animals as calculated by two-way ANOVA with Tukey post hoc test

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