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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury

Fig. 4

BET inhibition increases tissue preservation and neuronal survival after SCI. a, b Quantification of the percentage of white matter sparing, with respect to the total area of the spinal cord, from the injury epicenter up to 1000 μm rostral and caudally. c Percentage of total spared white matter in 2-mm spinal cord samples from different mouse groups. d Representative micrographs of sections stained with LFB at 300 μm rostral to the epicenter from vehicle-treated, JQ1 short-term-treated and JQ1 long-term-treated animals. e Quantification of ventral horn neuron survival from the injury epicenter to 800 μm rostral and caudally. f Representative micrographs showing sparing ventral horn neurons from vehicle-treated, JQ1 short-term-treated and JQ1 long-term-treated animals at 600 μm rostral to the lesion site. N = 4–5 mice per group. Scale bars, 500 μm (d, f). *p < 0.05, ***p < 0.005, and ****p < 0.001 compared to vehicle-treated group and #p < 0.05 and ####p < 0.001 compared to short-term-treated group as calculated by two-way ANOVA with Tukey post hoc test. Data are represented as mean ± SEM

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