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0
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No sign of disease; the tail is erect, and locomotor activity is intact
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0.5
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Tail is erect, but the tip is limp
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1.0
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Tail is limp but signs of movement remain. Locomotor activity is slightly impaired and hind legs are extended
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1.5
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Tail is limp and one of two hind legs appears to be weak. Balance is slightly impaired
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2.0
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Tail is limp with no signs of movement; both hind legs are weak. Locomotor activity is impaired, and mice show poor balance and may drag a hind leg. Even in the absence of uncoordinated movement, the mouse presents with inclined head and poor balance
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2.5
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Tail is limp, both hind legs are weak; one hind leg lacks movement or may be dragging
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3.0
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Tail is limp and both hind limbs are completely paralyzed. Locomotor activity is clearly impaired
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3.5
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Tail is limp and both hind limbs are completely paralyzed, partial front leg paralysis. Locomotor activity is clearly impaired. When turned on its side, mouse is unable to right itself
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4.0
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Tail is limp, complete hind leg, and partial front leg paralysis. In cases where the mouse reaches a score 4 for 2 consecutive days, euthanasia is recommended
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4.5
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Complete hind and partial front leg paralysis, no movement around the cage. Mouse is not alert. Euthanasia is recommended
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5.0
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Mouse is dead
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