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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit

Fig. 1

Illustration depicting the experiments and protocol applied. Adult female Wistar rats (250 to 300 g) received either a C7-T1 35g clip-compression injury or sham surgery (C7-T1 laminectomy). At 15 mins post-injury, a single bolus of hIgG (0.02, 0.2, 0.4, 1, or 2 g/kg), control buffer, and MPSS (immunosuppressant; 0.03 g/kg) were administered to the injured rats through the tail vein. At 24 hours (h) post-SCI, the spinal cord was collected from the rats for various assays to analyze the local acute inflammatory response. Another group of rats was used for VHRUS, Power Doppler, and immunohistochemistry (IHC) analyses. For protein and histology work, 2 cm of the spinal cord centered at the epicenter was obtained

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Journal of Neuroinflammation

ISSN: 1742-2094