Fig. 7

hIgG (2 g/kg) results in significant neurobehavioral improvement. a Illustration depicting the experiments and protocol applied. Adult female Wistar rats (250 to 300 g) received either a C7-T1 35 g clip-compression injury or sham surgery (C7-T1 laminectomy). At 15 min post-injury, a single bolus of hIgG (0.4 or 2 g/kg) or control buffer was administered to the injured rats through the tail vein. Functional recovery was assessed weekly by individuals blinded to the treatment groups for 6 weeks. b Relative to the control buffer and hIgG (0.4 g/kg), hIgG (2 g/kg) led to a significantly better improvement in the whole-body and trunk motor function, gross sensorimotor movement/hindlimb function, and grip strength as evaluated by the inclined plane, Beattie-Basso-Bresnahan, and grip strength, respectively. Improvements were mainly seen in weeks 4 and 5 post-SCI. hIgG had no effect on neuropathic pain after an injury. Two-way ANOVA, Tukey’s post-hoc test (*p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001 for comparisons between the control buffer and hIgG (2 g/kg), ^δp < 0.05, ^δδp < 0.01, ^δδδp < 0.001, ^δδδδp < 0.0001). Data are presented as mean ± SEM values