Fig. 1

MGL expression is upregulated in MS lesions. a Box plot showing the z-transformed expression values of MGL in NAWM and rim from chronic inactive (n = 7) and active (n = 7) MS lesions. *P < 0.05 (Kruskal-Wallis test followed by Dunn’s multiple comparisons test). b Expression of MGL in normal-appearing white matter (NAWM) and MS chronic inactive, chronic active, and active lesions. Consecutive brain sections from MS patients were stained for MGL and imaged by standard microscopy (representative of 3 donors). Scale bars, 50 μm. Insets, double staining showing the expression of MGL (red) and MHC II (green). Blue is a nuclear staining with DAPI. Images were collected from the same section with the same exposure time between different areas to allow comparison. Scale bars, 15 μm