Fig. 6

Cells from Clec10a^−/− mice are more susceptible to MGL1-induced cell death. a, b Wild-type (WT) and MGL1-deficient (Clec10a^−/−) mice were immunized with MOG_35–55 for EAE induction. At 27 dpi, DLN cells were isolated and incubated in the presence or absence of MGL1-Fc or MGL2-Fc. a After 30 min of incubation, cells were stained with anti-human IgG Fc to determine MGL1/2 binding and gated on MHC II⁻ cells. b Cell death was evaluated by AV binding after ON incubation. Mean ± SEM. Student t test, **P < 0.01