Fig. 3

The absence of Oct1 in T cells does not impact disease in JHMV-infected mice. a CD4-Cre;Oct1^fl/fl (n = 15) or Oct1^fl/fl mice (n = 14) were infected i.c. with 200 PFU of JHMV and disease severity assessed. Clinical disease was recorded to day 21 p.i. b Brain viral titers were determined at days 7 and 21 p.i., (n.d., not detected). c Representative LFB stained thoracic spinal cord sections from experimental mice at day 12 p.i. d Quantification of average demyelination from CD4-Cre;Oct1^fl/fl (n = 4, 12 dpi; n = 3, 21dpi) and Oct1^fl/fl mice (n = 3, 12 dpi; n = 5, 12 dpi) at days 12 and 21 p.i