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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity

Fig. 5

Ingenuity Pathway Analysis (IPA) of DE genes between CD11b+CD45lo and CD11b+CD45hi cells. a IPA reveals the top 15 canonical pathways based on the DE genes comparing CD11b+CD45lo and CD11b+CD45hi cells in CD or WD diet-fed mice [−log10(p value) > 1.3]. b–d Box plots showing the expression levels of the representative genes in CD11b+CD45lo and CD11b+CD45hi cells in granulocyte or agranulocyte adhesion and diapedesis (b), atherosclerosis signaling (c), and TREM1 signaling pathways (d). e–f Pathway network illustration of atherosclerosis signaling (e) and TREM1 signaling (f) pathways in WD-fed mice. The molecules in red indicate their significantly increased expression in CD11b+CD45hi cells compared to CD11b+CD45lo cells

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