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Table 1 Demographic, plasma YKL-40 concentrations and diagnostic accuracy in discrimination from healthy controls and neurological disease groups

From: Plasma YKL-40 in the spectrum of neurodegenerative dementia

  n Sex (f/m) Age (years) YKL-40 (ng/mL) AUC (95% CI)
Mean + SD 95% CI vs. HC vs. ND
HC 70 22/48 66 ± 5 84 ± 84 63–104   0.64 (0.53–0.74)
ND 44 26/18 66 ± 12 95 ± 61 76–114 0.64 (0.53–0.74)  
AD 50 25/25 69 ± 10 133 ± 110 102–164 0.62 (0.51–0.73) 0.55 (0.43–0.67)
VaD 22 8/14 72 ± 10** 140 ± 150 73–206 0.56 (0.40–0.72) 0.51 (0.34–0.68)
FTD 17 11/6 68 ± 12 125 ± 108 69–181 0.65 (0.50–0.80) 0.55 (0.38–0.73)
CJD 78 51/27 67 ± 8 189 ± 167 151–227 0.81 (0.74–0.88) 0.72 (0.63–0.81)
LBD 34 13/21 69 ± 8 167 ± 157 112–222 0.70 (0.59–0.81) 0.63 (0.49–0.76)
  1. Number of cases (n), sex (female [f]/male [m]), age in years (mean values ± standard deviation (SD)), YKL-40 plasma concentrations (mean values ± SD) and 95% confidence interval (95% CI)) and area under the curve (AUC) with 95% CI values for each dementia diagnostic comparison versus HC and ND are indicated
  2. **p < 0.01