Fig. 6

Quantitative and histological illustration of vascular amyloid burden. a Vascular amyloid burden in Tg-SwDI mice, represented as percent of the vasculature covered by fibrillar amyloid in the cortex, subiculum, and thalamus. This measure was calculated as [(ThioflavinS⁺ stain/Collagen IV⁺ stain) × 100]. WT mice were not included in this analysis, as only Tg-SwDI mice exhibit measurable amyloid pathology. Brains were collected following the 8-month exercise intervention period and completion of behavior testing. ^p < 0.05 versus Tg-SwDI sedentary. b Representative images of histological staining from thalamus (scale bars = 50 μm) for fibrillar Aβ (Thioflavin-S; green) and blood vessels (collagen IV; red) in sagittal sections from Tg-SwDI mouse brains