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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner

Fig. 7

Sulfadiazine treatment prevents T. gondii infection-induced decrease of synapse-related gene expression. Non-infected, T. gondii-infected, H. polygyrus-infected, and co-infected mice were treated with sulfadiazine, and RNA isolated from whole brain homogenate were isolated. a–e qRT-PCR data for relative expression of mRNA from non-infected (Non.Inf.), non-infected + sulfadiazine treatment (Non.Inf.+sulfa), T. gondii-infected (Tg), T. gondii-infected + sulfadiazine treatment (Tg+sulfa), T. gondii and H. polygyrus co-infected (Tg+Hp), T. gondii and H. polygyrus co-infected + sulfadiazine treatment (Tg+Hp+sulfa), H. polygyrus-infected (Hp), and H. polygyrus-infected + sulfadiazine treatment (Hp+sulfa) mice. Relative mRNA levels were normalized to the mean of the non-infected control group (Non.Inf.). Bars represent mean±SEM

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Journal of Neuroinflammation

ISSN: 1742-2094