Fig. 8

IFN-γ neutralization partially prevents synaptic gene expression, decreases iNOS, CD36, TREM2, C1qa expression and enhances parasite burden in the CNS. Co-infected mice were treated with 0.5 mg of anti-IFN-γ or IgG1 at days 14, 17, 20, 23, and 26 post-infection. a–k qRT-PCR data for relative expression of mRNA in brain cortex homogenate from non-infected (Non.Inf.), T. gondii-infected (Tg), T. gondii and H. polygyrus co-infected with IgG1 injection (Tg+Hp), T. gondii and H. polygyrus co-infected with IFN-γ neutralization (αIFN-γ), and H. polygyrus-infected (Hp) mice. Relative mRNA levels were normalized to the mean of the non-infected control group (Non.Inf). Bars represent mean ± SEM