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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Systemic TLR2 tolerance enhances central nervous system remyelination

Fig. 6

Demyelination in WT versus TLR2−/− mice after 5 weeks on cuprizone and 2 weeks on normal chow. WT and TLR2−/− mice were fed either cuprizone or normal chow for 5 weeks, then all mice were fed normal chow for 2 weeks (“recovery period”). At the end of the 2-week recovery period, myelin status in the corpus callosum was analyzed by EM. a Myelin thickness (g-ratios) of normal (“NL”) chow-fed WT versus TLR2−/− mice. b Myelin thickness of cuprizone (“Cup”)-fed WT versus TLR2−/− mice. c Percentage of unmyelinated axons in normal chow-fed WT versus TLR2−/− mice. d Percentage of unmyelinated axons in cuprizone-fed WT versus TLR2−/− mice. Data points represent individual mice analyzed as described in the “Methods” section. N = 7 mice per experimental condition. Error bars represent the mean ± SEM. Statistical differences were assessed by Mann-Whitney analysis. ***p < 0.001. For NS comparisons: a NL chow: WT vs TLR2−/−, p = 0.9656. c NL chow: WT vs TLR2−/−, p = 0.9636

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